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COMMENTARY | Republican presidential hopeful Rick Santorum suspended his bid for the GOP nod to run against Barack Obama when his daughter, Bella Santorum, was hospitalized, according to the Associated Press. Bella suffers from Trisomy 18, a rare genetic disorder in which a baby has some or all of an extra chromosome. While it is always tragic for a parent to face losing a child, the situation highlights a political issue: Santorum's hypocrisy on health care, abortion and embryonic stem cell research.
Santorum's campaign website discusses his views on these matters. He is emphatically against a woman's right to control her own body in reproductive matters and is adamantly opposed to embryonic stem cell research. He is against a single-payer national health care system provided to all citizens. He opposes the first two on religious grounds on the third for reasons of political dogma.
As to abortion, Santorum flip-flops on his opposition, according to a Care2.com report. It's easy for him to rail against abortion when such ranting might win him votes.
It's also easier for him to oppose it because he has the best health care in America available to him and his family -- provided at taxpayer expense, no less. He never had to consider whether care for a terminally ill child would destroy his family financially.
Unless the U.S. enacts a national health care plan most families will never be able to afford the care needed for a child with Trisomy 18. Santorum's family will never lack for health care or face crippling medical debt -- but as far as he's concerned it's fine for your family to have those problems.
Santorum's opposition to embryonic stem cell research is ludicrous for two reasons. First, such research involves the collection of cells from a blastocyst, a blob of about 150 cells so small the human eye cannot detect it, according to the National Institute for Health. Second, such research could save the lives of his daughter and countless others suffering from her condition. It's despicable for him to fight against the best possible hope for a cure to the very condition killing his child.
It makes me wonder how Santorum's opinion might change if he was an average American with a household income of less than $50,000 per year and no health insurance. I bet he'd sing a different tune.
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TOKYO ? Japan's rapid aging means the national population of 128 million will shrink by one-third by 2060 and seniors will account for 40 percent of people, placing a greater burden on the shrinking work force population to support the social security and tax systems.
The population estimate released Monday by the Health and Welfare Ministry paints a grim future.
In year 2060, Japan will have 87 million people. The number of people 65 or older will nearly double to 40 percent, while the national work force of people between ages 15 and 65 will shrink to about half of the total population, according to the estimate, made by the National Institute of Population and Social Security Research.
The total fertility rate, or the expected number of children born per woman during lifetime, in 2060 is estimated at 1.35, down from 1.39 in 2010 ? well below more than 2 needed to keep the country's population from declining. But the average Japanese will continue to live longer. The average life expectancy for 2060 is projected at 90.93 for women, up from 86.39 in 2010, and 84.19 years for men, up from 79.64 years.
Prime Minister Yoshihiko Noda has pledged to push for social security and tax reforms this year. A bill he promised to submit by the end of March would raise the 5 percent sales tax in two stages to 8 percent in 2014 and 10 percent by 2015, although opposition lawmakers and the public pose challenges to its approval.
Experts say that Japan's population will keep losing 1 million every year in coming decades and the country urgently needs to overhaul its social security and tax system to reflect the demographic shift.
"Pension programs, employment and labor policy and social security system in this country is not designed to reflect such rapidly progressing population decline or aging," Noriko Tsuya, a demography expert at Keio University, said on public broadcaster NHK. "The government needs to urgently revise the system and implement new measures based on the estimate."
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LONDON (Reuters) ? Foreign troops must carefully phase their withdrawal from Afghanistan ahead of an end-2014 deadline, British Prime Minister David Cameron said on Saturday, after France suggested giving Afghan forces full responsibility for security in 2013.
"I don't want to see some sort of cliff edge in 2014 when all of the remaining troops come out at once," Cameron said during talks in London with Afghan President Hamid Karzai.
"But clearly, between now and 2014, the rate at which we can reduce our troops will depend on the transition to Afghan control in the different parts of Afghanistan..."
French President Nicolas Sarkozy said on Friday France would pull its combat troops out at the end of 2013, a year before an end-2014 deadline fixed by the United States and its NATO allies for handing over responsibility for security to Afghan forces.
"We have decided, in agreement with President Karzai, to call on NATO to give some serious consideration to the Afghan army taking full charge of NATO combat missions in the course of 2013," Sarkozy said at a news conference with Karzai in Paris.
He said he would raise this at a meeting of NATO defence ministers in Brussels on Feb 2 and 3.
However, some foreign troops, Sarkozy said, would stay on after 2013 to train the Afghan army - which western countries are building up with the aim of making it strong enough to maintain security without outside help after the end of 2014.
Foreign countries are already handing over responsibility for security in parts of Afghanistan to Afghan forces.
The idea of speeding up that transfer has been floated in the past, in part to provide a cushion to Afghan forces to take charge of security at a time when foreign troops would still be available to help in an emergency.
It was unclear whether Sarkozy's suggestion was meant merely to feed into this debate, or whether he was expecting the United States and its allies to agree to a serious acceleration in handing over to Afghan forces.
In Washington, U.S. defence officials said the United States, which has the lion's share of foreign troops in Afghanistan, was standing by NATO's goal of gradually handing over security responsibilities to Afghan forces by 2014.
"That transition has begun, and we have made considerable progress toward this goal over the past year, thanks to the gains of the military surge and the development of Afghan security forces," Pentagon press secretary George Little said.
Consultations on transition would continue at the meeting in
Brussels next week, he said, ahead of a NATO summit due in Chicago in May.
A U.S. defence official said that, "U.S. forces continue to plan to transition through to the end of 2014. Our policy has not changed."
In Brussels, a NATO spokeswoman echoed the Pentagon's comments, saying "transition is well on track to be completed by the end of 2014, as we all agreed."
SUPPORT AFTER 2014
Foreign countries have promised to support Afghanistan with aid and advice for years after combat troops leave.
But they have scaled back their ambitions for Afghanistan to seek a minimum level of stability that would prevent the country from again becoming a haven for al Qaeda.
The United States also began talks with Taliban insurgents in late 2010 in a slow-moving process to try to reach, or at least begin to shape, a political settlement by the end of 2014.
With the western troop presence becoming increasingly unpopular inside Afghanistan, some officials have said the withdrawal of troops might make it easier to reach a settlement with insurgents - who use their opposition to foreign forces to rally support.
Cameron plans to pull out 500 British soldiers this year but has not yet set out a timetable for further withdrawals.
He made clear, however, that British combat troops would stay to the end of 2014 - though Britain has said it will not expand its area of operations in southern Afghanistan to fill in for departing troops from other countries.
"We ... want to have a long-term relationship with Afghanistan, long after our combat troops come home, and that will happen at the end of 2014," he said.
Britain has some 9,500 troops in Afghanistan as part of the 130,000-strong NATO-led force. U.S. forces number some 90,000. France has 3,600 troops in Afghanistan.
Karzai and Cameron signed a partnership agreement setting out how their countries would work together after 2014.
Karzai said the agreement "will take us into a future where Afghanistan will benefit from the assistance and cooperation and help of Britain towards becoming a fundamentally strong democratic state." The Afghan president was asked no questions at a tightly controlled media event.
(Additional reporting by Tim Castle in London, David Alexander in Washington, John O'Donnell in Brussels; Editing by Myra MacDonald)
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LONDON (Reuters) ? Oil giant BP has lost its attempt to shift over $15 billion of costs related to the Gulf of Mexico oil spill onto contractor Transocean, increasing the possibility BP may have to foot the entire $42 billion clean up bill.
A U.S. federal judge on Thursday said BP must uphold a clause in its contract with Transocean Ltd that would shield the Swiss-based driller from compensatory damage claims related to the 2010 disaster.
That means London-based BP may have to shoulder alone compensation claims brought by the likes of fishermen and hoteliers whose livelihoods were affected by largest offshore oil spill in U.S. history.
However, U.S. District Judge Carl Barbier left open the possibility that Transocean might still have to pay all or part of any punitive damages and civil penalties imposed by the U.S. government under the federal Clean Water Act.
Barbier, who oversees multistate litigation over the spill, ruled that BP need not indemnify Transocean for these.
BP has estimated civil fines of around $3.5 billion related to the spill, although maximum possible fines could top $20 billion if gross negligence was established on the part of BP or its contractors.
BP has made no provision for punitive damages because it says there is no legal basis for them. Barbier has limited the cases in which claims for punitive damages can be brought.
Thursday's decision means Transocean's potential liability over the April 20, 2010 Deepwater Horizon drilling rig explosion that caused 11 deaths, was "materially diminished" analysts at UBS said in a research note.
BP had previously sought to shift the whole cost of the disaster, currently estimated at around $42 billion, onto Transocean.
Shares of Transocean rose 8.2 percent at 0856 GMT, while BP shares fell 1.7 percent.
RESPONSIBILITY
Transocean owned the rig, while BP owned a majority of the Macondo well whose blowout led to the spill.
BP has said it would like to reach an out of court settlement with Transocean but Barbier's ruling makes its negotiating position weaker.
Both sides claimed victory over the ruling, which Transocean spokesman Lou Colasuonno said "discredits BP's ongoing attempts to evade both its contractual and financial obligations."
BP said the decision "holds Transocean financially responsible for any punitive damages, fines and penalties flowing from its own conduct.
"As we have said from the beginning, Transocean cannot avoid its responsibility for this accident," spokesman Daren Beaudo said in an emailed statement.
LEGAL ARGUMENTS
BP has already paid out $7 billion in claims to third parties who have suffered losses and has an outstanding provision of $8.2 billion for further claims and litigation, suggesting third party claims are expected to top $15 billion.
However, plaintiffs lawyers say compensatory claims could even end up totaling more than the $20 billion BP has set aside in its gulf coast restoration fund.
Two U.S. government probes have put most of the blame for the disaster on BP, suggesting BP is likely to face the largest share of any fines levied.
The New Orleans-based judge has set a February 27 start date for a trial to apportion blame.
The case is In re: Oil Spill by the Oil Rig "Deepwater Horizon" in the Gulf of Mexico, on April 20, 2010, U.S. District Court, Eastern District of Louisiana, No. 10-md-02179.
(Writing by Tom Bergin; Additional reporting by Jonathan Stempel; Editing by Jodie Ginsberg)
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KABUL (Reuters) ? Senior Afghan peace negotiators believe the Taliban are willing to significantly soften past hardline ideologies, with its leaders already laying the ground for possible peace talks in the Gulf state of Qatar.
Former Taliban minister Maulvi Arsala Rahmani, a member of the High Peace Council set up by President Hamid Karzai two years ago to liaise with insurgents, said that after a decade of fighting with NATO, the Taliban were ready to moderate on reimposition of fundamentalist positions.
And despite the assassination only last September of former president and leader of the peace process Burhanuddin Rabbani, secret discussions that began in Germany in November 2010 between U.S., Taliban, German and Qatari representatives had a good chance of success, Rahmani said.
"The Taliban are not back to govern the same way as the old Islamic Emirate of Afghanistan. When they are back, they will be back as Afghans," Rahmani, a Taliban defector but with strong ties to the movement, said at his sparsely furnished home in a part of western Kabul heavily damaged during the country's bloody civil war.
"For Taliban members with the talent and skills, they will be election candidates for parliament, the presidency or the cabinet. The Taliban are not back to take over Afghanistan," he said.
Martine van Bijlert, of respected independent think-tank Afghanistan Analysts Network in Kabul, said no one could assume that talks with the Taliban would not work.
"But at the same time, we can't get ahead of ourselves," she said. "There seems to be a real chance at the moment. The high council has an interest in optimism of course, given their role in the process. But whether it can work is a fine balance. There is not an option not to try."
The Taliban announced this month that it would open a political office in Qatar to support possible peace talks with the United States and key allies, seen by backers like Rahmani as the best chance of reaching a ceasefire ahead of a withdrawal of foreign combat troops in 2014.
As a confidence-building measure, the Islamist group which ruled Afghanistan from 1996 until the U.S.-led invasion of the country in late 2001 called for the release of five members being held at Guantanamo Bay, a U.S. military enclave in Cuba.
Rahmani said preparations in Qatar were under way, with a team of senior aides to the Taliban's one-eyed leader Mullah Mohammad Omar already in Doha.
"I think the (Qatar) office is operational, but media are strictly banned," he said, looking frail with age and swathed in a heavy, fur-lined coat against the winter cold.
"People are already there like Shahabuddin Delawar (a former Taliban envoy to Saudi Arabia), Sher Mohammad Abbas Stanekzai (a former Taliban deputy foreign minister) and Tayeb Agha (said to be a close aid and former secretary to Mullah Omar)."
Talks could begin in weeks and Rahmani said he expected that junior Taliban fighters would accept any peace agreed by their leaders if negotiations with U.S. and Afghan government officials proved ultimately successful.
"Those who fight on the field take their instruction from the leaders. The soldiers will not fight, or have someone else organize them and supply them. To say otherwise just looks like propaganda to me," he said.
TALIBAN SPLIT
But Mohammad Ismail Qasimyar, another peace council member and its adviser on foreign relations, said while he saw signs of moderation among the Taliban leadership, a peace deal had the potential to split junior members with more hardline views away from Taliban, possibly to continue a lower-level war.
"I would not dare to say all of the Taliban are thinking the same," said Qasimyar, appointed to the council of 62 men and eight women along with Rahmani in 2010.
"Some, especially the leadership, have changed hearts and minds. But the new recruits and younger ones, they are more ideological. I don't think they will change, but the majority will join the peace process," he said.
While a Qatar office for the Taliban was already a reality, Qasimyar said more had to be done before it could be called officially open. A Taliban spokesman told Reuters he could not comment on the progress of preparations.
And Qasimyar said Pakistan, seen by some political analysts as a possible disgruntled spoiler in the process because of its longstanding demand to have a big say in Afghanistan's future, had been quietly supportive, helping move Taliban named on a United Nations travel blacklist.
Pakistan, and its powerful military and intelligence service ISI, has consistently denied meddling in Afghanistan, but Islamabad had pushed for a Taliban office in the Turkish capital Ankara or Saudi Arabia's Riyadh, because of Pakistan's close ties with both countries.
Qasimyar said the Taliban had no choice but to compromise in a peace process he believed could be concluded "in a couple of years," embracing other insurgent groups as well as Afghan ethnic groups which fought brutal Taliban rule.
But Afghanistan could eventually emerge with a different shape of government, possibly with a stronger parliamentary system and less power in the hands of the presidency, he said.
"The constitutional system has to prevail," he said. "But if we all agree, and we all come into a peace agreement and we all come back to our country, all of us here, then we have to think about amendments to the constitution, amended through the machinery that is set up in the constitution."
(Editing by Nick Macfie)
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Spacetime Studios, creators of Pocket Legends and Star Legends, are returning to Android with their latest creation; Dark Legends. Release for this taste of the undead is currently slated for Q1 2012.
The gameplay of Dark Legends is said to draw the player deeper into the experience. Boasting a combat system that features new mechanics such as charge attacks and the ability to drain enemies.
The game will also be more focused on the narrative aspect, and will offer the ability to complete quick action missions with a single tap. Such missions feature cut-scenes that become linked together to create a storybook where the player experiences the life of a vampire up close and personal.
The game is said to open with your character recently 'raised' and being watched over by the vampire that created them. The existance of vampires has been exposed and the humans are uniting to exterminate them all. You must work with your clan to survive.
The previous games from Spacetime have been downloaded over 7 million times and offer players such a high level of gaming quality. There's no reason to suspect Dark Legends will be any different. It is due to be shown off for the first time at GDC 2012.
via Marketwatch; More: Spacetime Studios
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Cancer treatments designed to block the growth of blood vessels were found to increase the number of cancer stem cells in breast tumors in mice, suggesting a possible explanation for why these drugs don't lead to longer survival, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
The drugs Avastin and Sutent have been looked at as potential breast cancer treatments. But while they do shrink tumors and slow the time till the cancer progresses, the effect does not last, and the cancer eventually regrows and spreads.
"This study provides an explanation for the clinical trial results demonstrating that in women with breast cancer antiangiogenic agents such as Avastin delay the time to tumor recurrence but do not affect patient survival. If our results apply to the clinic, it suggests that in order to be effective, these agents will need to be combined with cancer stem cell inhibitors, an approach now being explored in the laboratory," says study author Max S. Wicha, M.D., director of the U-M Comprehensive Cancer Center.
The researchers treated mice with breast cancer using Avastin (bevacizumab) and Sutent (sunitinib), both of which work by stopping the growth and formation of blood vessels, a process called angiogenesis. The researchers found that tumors treated with these drugs developed more cancer stem cells, the small number of cells within a tumor that fuel a cancer's growth and spread and that are often resistant to standard treatment. Both the number of cancer stem cells and the percentage of cancer stem cells that make up the tumor increased after being treated with each of these therapies.
The researchers found that the cancer stem cells increased because of a cellular response to low oxygen, a condition called hypoxia. And they were able to determine the specific pathways involved in hypoxia that activate the cancer stem cells.
Results of the study appear online in the Proceedings of the National Academy of Sciences Early Edition.
The U.S. Food and Drug Administration recently revoked approval of Avastin for treating breast cancer, although the drug is approved for use in other types of cancer. The reversal was in response to clinical trials showing that the drug's benefit was short-lived, with breast cancer patients quickly relapsing and the cancer becoming more invasive and spreading further throughout the body. Overall, the drug did not help patients live any longer.
The current study suggests the possibility of combining anti-angiogenesis drugs with a cancer stem cell inhibitor to enhance the benefit of this treatment. The researchers are testing this approach in mice and preliminary data looks promising.
Breast cancer statistics: 209,060 Americans will be diagnosed with breast cancer this year and 40,230 will die from the disease, according to the American Cancer Society
###
University of Michigan Health System: http://www.med.umich.edu
Thanks to University of Michigan Health System for this article.
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NEW YORK ? The nation's natural gas supplies declined last week, the government said Thursday.
The Energy Department's Energy Information Administration said in its weekly report that natural gas in storage shrank by 192 billion cubic feet to 3.098 trillion cubic feet for the week ended Jan. 20.
Analysts expected a drop of 171 billion to 175 billion cubic feet, according to a survey by Platts, the energy information arm of McGraw-Hill Cos.
Although last week's decline was larger than the five-year average draw of 173 billion cubic feet, the inventory level was still 21.4 percent above the five-year average of 2.551 trillion cubic feet, and 20.7 percent above last year's level of 2.567 trillion cubic feet, according to the government data.
Mild winter weather has kept thermostats down and natural gas supplies high.
Natural gas futures fell 3 cents to $2.70 per 1,000 cubic feet in New York.
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NEW YORK ? About 12 groups submitted initial bids to buy the Los Angeles Dodgers from Frank McCourt, several people familiar with the process said Tuesday.
Among the bidders were Dallas Mavericks owner Mark Cuban and former YES Network chief executive officer Leo Hindery, two people said, speaking on condition of anonymity because the bids were to remain confidential.
One of the people also confirmed a Los Angeles Times report that Stan Kroenke was involved in the bidding. Kroenke already controls the NFL's St. Louis Rams, the NBA's Denver Nuggets, the NHL's Colorado Avalanche, Arsenal of the English Premier League and Major League Soccer's Colorado Rapids.
Hindery's bid, made with Marc Utay, was first reported by the Wall Street Journal.
Bidders said they were waiting to hear from Blackstone Group, which is representing McCourt, what the next step in the process will be. Blackstone may ask Major League Baseball to conduct due diligence on up to 10 bidders, with each chosen group paying MLB $25,000 to cover baseball's costs.
McCourt is to pick his chosen owner by early April, with Major League Baseball approving the sale in time for a transfer by April 30, the day McCourt must pay former wife Jamie a $131 million divorce settlement.
Some of the other groups include former Los Angeles Lakers star Magic Johnson, former Dodgers manager Joe Torre, former Dodgers owner Peter O'Malley and former agent Dennis Gilbert.
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LONDON (Reuters) ? For Daniel Radcliffe, it's time to forget Harry Potter. The 22-year-old actor, inextricably linked to the boy wizard he played throughout the movie franchise, takes on his first adult role in Victorian-era horror film "The Woman in Black."
Hitting theatres in Britain on February 10 and a week earlier in the United States, the movie is a step into the unknown for an actor who grew up on the set of one of Hollywood's most successful series.
Instead of production budgets of $250 million or more, The Woman in Black cost an estimated $17 million to make. And however big Radcliffe's fan base around the world, another billion-dollar box office looks out of the question.
James Watkins, who directed The Woman In Black, called it a "reinvention" for Radcliffe.
"I think it's the start of that, absolutely," Radcliffe told Reuters in an interview ahead of Tuesday's red carpet world premiere of the new movie.
One of the attractions of playing Arthur Kipps, a young lawyer and father mourning the death of his wife, was the obvious break with what went before.
"People haven't seen me looking like this before. People haven't seen me playing a father -- all those things are going to help separate it in their mind," Radcliffe said.
"But I think ultimately the thing that will help that reinvention is the fact that the story is so good. I think people will very quickly forget that they're watching Harry Potter."
CREEPY MANSION
In The Woman in Black, Kipps is forced to leave his three-year-old son and travel to a remote village on the east coast of England to look into the legal affairs of the recently deceased owner of Eel Marsh House, a creepy mansion cut off from the mainland when the tide rises.
He discovers a dark family secret that helps explain the appearance of a mysterious, ghost-like woman dressed in black who beckons children to an early grave.
The film is based on a novel by Susan Hill that was adapted into a successful West End play, still running in London.
Jane Goldman, who co-wrote the scripts for "Kick-Ass" and "The Debt," was brought in to translate the page to the big screen, and horror specialist Watkins directed.
Radcliffe said he did not think too hard about trying to be different from his Harry Potter character when he worked on the set of The Woman in Black and was pleased with the results.
"I think my work in this is certainly on a par with the work I did on the last Potter which I was very, very proud of."
He will soon discover if critics agree. Throughout the Harry Potter series Radcliffe earned mixed reviews, although any negative comments did nothing to deter record audiences.
And his two main stage roles -- "Equus" in 2007 and "How to Succeed In Business Without Really Trying" in 2011 were generally well-received, particularly Equus.
Looking ahead, Radcliffe said proving he was not a one-part wonder would take time.
"It's a long road. It's not going to be one film and suddenly you're off. It's going to be a combination."
That combination will involve both stage and screen.
"In an ideal world I would like to mix them as much as possible. In March I'm filming a movie called 'Kill Your Darlings' in which I'll be playing a 19-year-old Allen Ginsberg.
"That's the next thing on the plate and after that we'll see."
(Reporting by Mike Collett-White)
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By Associated Press
A family spokesman says actor James Farentino, who appeared in dozens of movies and television shows, has died in a Los Angeles hospital. He was 73.
Family spokesman Bob Palmer says Farentino died of heart failure after a long illness at Cedars-Sinai Hospital on Tuesday.
Farentino starred alongside Kirk Douglas and Martin Sheen in a 1980 science fiction film "The Final Countdown."
Farentino also starred opposite Patty Duke in 1969's "Me, Natalie."
He also had recurring roles on "Dynasty," "Melrose Place," "The Bold Ones: The Lawyers" and "ER," playing the estranged father to George Clooney's character.
A four-time divorcee, Farentino's tumultuous personal life made headlines, too.
In March 1994 he pleaded no contest to stalking his ex-girlfriend Tina Sinatra, daughter of Frank Sinatra.
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A healthy genome is characterized by 23 pairs of chromosomes, and even a small change in this structure ? such as an extra copy of a single chromosome ? can lead to severe physical impairment. So it's no surprise that when it comes to cancer, chromosomal structure is frequently a contributing factor, says Prof. Ron Shamir of the Blavatnik School of Computer Science at Tel Aviv University.
Now Prof. Shamir and his former doctoral students Michal Ozery-Flato and Chaim Linhart, along with fellow researchers Prof. Shai Izraeli and Dr. Luba Trakhtenbrot from the Sheba Medical Center, have combined techniques from computer science and statistics to discover that many chromosomal pairs are lost or gained together across various cancer types. Moreover, the researchers discovered a new commonality of chromosomal aberrations among embryonic cancer types, such as kidney, skeleton, and liver cancers.
These findings, recently published in Genome Biology, could reveal more about the nature of cancer. As cancer develops, the genome becomes increasingly mutated ? and identifying the pattern of mutation can help us to understand the nature and the progression of many different kinds of cancer, says Prof. Shamir.
Looking at the big picture
As cancer progresses, the structure of chromosomes is rearranged, individual chromosomes are duplicated or lost, and the genome becomes abnormal. Some forms of cancer can even be diagnosed by identifying individual chromosomal aberrations, notes Prof. Shamir, pointing to the example of a specific type of leukemia that is caused by small piece of chromosome 9 being moved to chromosome 22.
When analyzing many different kinds of cancer, however, the researchers discovered that chromosomal aberrations among different cancers happen together in a noticeable and significant way. The researchers studied a collection of more than fifty thousand cancer karyotypes ? representations of chromosomal layouts in a single cell ? and charted them according to commonalities. The researchers were not only able to confirm different chromosomal aberrations that appeared in specific cancer types, but also for the first time identified a broader effect of pairs of chromosomes being lost or gained together across different cancer types.
It was also the first time that researchers saw a connection among solid kidney, skeleton, and liver cancers. While it was known that these cancers all develop in the embryo, they were previously analyzed independently. The TAU researchers have now confirmed that they share chromosomal characteristics and aberrations, much like various forms of leukemia or lymphomas.
Aberrations a driving force for cancer
Under normal circumstances, even a small change to a person's chromosomal structure can be devastating. For example, Down's syndrome is caused by a single extra copy of Chromosome 21. "But in cancer, there are many cases of extra or missing chromosomes. Yet cancer cells thrive more effectively than other cells," Prof. Shamir says.
Prof. Shamir hopes that future investigation into these chromosomal aberrations will give researchers more clues into why something that is so detrimental to our healthy development is so beneficial to this disease. Cancer is the result of sequences of events, he says, each causing the genome to become more mutated, mixed, and duplicated. Tracking these changes could aid our understanding of the driving forces of cancer's progress.
###
American Friends of Tel Aviv University: http://www.aftau.org
Thanks to American Friends of Tel Aviv University for this article.
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Source: http://www.labspaces.net/116946/Patterns_of_chromosome_abnormality__The_key_to_cancer_
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NEW YORK (Reuters) ? Stocks rising, bulls rampant are motifs you might pick if designing a coat of arms for Wall Street at the moment. But the motto should read: Caveat emptor. Yes, buyer beware.
The S&P 500, a broad measure of the market valuation of the biggest U.S. publicly traded companies, is up 20 percent from its October closing low. It keeps climbing on a mixed bag of fourth-quarter earnings, improving U.S. economic data, and easing credit conditions in Europe. It now stands at its highest level since early last August.
We have already seen what is probably the first upgrade of a target level for the index this year courtesy of Credit Suisse.
The CBOE Volatility Index, or VIX (.VIX), a measure of what investors are paying to protect themselves against the risk of losses, is at its lowest level in seven months.
So it raises the question: Is this another Jackson Hole moment for risk assets?
At the Wyoming retreat in late August 2010, Federal Reserve Chairman Ben Bernanke sparked what was the second major leg of the stock market's rally from bear market lows the year before.
Is this the start of the third?
FRIENDLIER FOOTING FOR STOCKS
For Andrew Garthwaite, the Credit Suisse analyst behind the firm's more bullish stance, there are big changes afoot that are creating a more benign environment for stocks.
First, the European Central Bank's long-term repo operations are succeeding in reducing stresses in the region's banking sector. This week, three-month dollar Libor, the cost at which European banks can borrow dollars, marked its ninth straight day of declines.
Analysts say heavy cash infusions from the European Central Bank since late last year and signs of revived willingness to lend by U.S. investors in the new year show the banking system is flush with cash.
The U.S. economy is looking stronger than thought, with notable movement in the long-dormant housing market, where sales of previously owned homes just rose to an 11-month high.
In China, the engine of global growth whose manufacturing sector has been showing worrying signs of slowing, policymakers have demonstrated willingness to make conditions easier by lowering banks' reserve requirements.
"As we approach our year-end target two weeks into January, we have to ask ourselves the following questions: What has changed? Will equities rally further?," Garthwaite said in a research note.
His answer to the second question was yes. Credit Suisse raised its year-end S&P 500 target to 1,400 from 1,340. Critically, however, the firm did not overweight equities, saying the risks of a more severe recession in Europe and a slowdown stateside were still there.
HEALTHY DOSE OF SKEPTICISM
For Nicholas Colas, chief market strategist at the ConvergEx Group in New York, the rally remains largely untested. More scary headlines from Europe or any signs that the global economy is deteriorating could spark a sharp reversal.
On Sunday, Greece's private creditors were working closely with the Greek government on a debt-swap deal, according to their chief negotiator, Charles Dallara, the head of the International Institute of Finance. Dallara told Antenna TV in Greece that he is confident that a deal can be reached. [ID:nL5E8CM0HB] Creditors faced losses of up to 70 percent of the loans they have given to Athens.
Most of the attention will now shift to a Monday meeting of euro-zone finance ministers, and to how EU states and the IMF view the progress in the debt-swap talks.
"It's a confidence-based rally with the overhang of several still meaningful events to come," Colas said. "It is all well and good to say that the Greek default is well understood, but we haven't gone through it."
Outside the United States, there are mixed signals from the global economy, too.
China's factory activity likely fell for a third successive month in January. The HSBC flash manufacturing purchasing managers index (PMI), the earliest indicator of China's industrial activity, stood below 50.
The Baltic Exchange's main sea freight index (.BADI), which tracks rates to ship dry commodities and can be a useful gauge of economic activity, fell to its lowest level in three years on Friday on a growing surplus of vessels and a slump in cargo demand.
That is at odds with the work of RBC technical analyst Robert Sluymer. He sees growing outperformance of industrial metal copper to the safe-haven bet of gold as well as a rise in a basket of Asian currencies as a bullish sign for the economy.
The caution generated by the mismatches in the various data points is reflected by U.S. interest rates.
The yield on the U.S. 10-year Treasury note has hovered at 2 percent or just below for the last month despite a brief spike in mid-December. That suggests bondholders are not eagerly embracing the improving economy thesis for the moment.
"There is still a lot of skepticism about recovery, about moving into risk assets, about a lot of things," Colas said.
"If you really wanted to believe this about incrementally economic certainty and expansion ... I would have thought you'd expect to see the 10-year back over 2 percent."
EARNINGS, DATA AND THE FED
Monday will start one of the two most hectic weeks of the earnings season. Big names on Monday's earnings roster include Texas Instruments Inc (TXN.O) and Halliburton Co (HAL.N).
The blitz of earnings plus economic indicators and a Federal Reserve meeting will give Wall Street an important gauge of the economy's health - and the outlook for interest rates.
On Tuesday, the Federal Reserve's policymakers will convene their first meeting of the year with a two-day session. The Federal Open Market Committee, the Fed's rate-setting panel, will release its policy statement on Wednesday. No fireworks are expected, but a decision to release individual policymakers' interest-rate forecasts could alter expectations for rates on the margins.
This week's economic data will include December pending home sales data on Wednesday and a trio of reports on Thursday, when the latest weekly jobless claims, December durable goods orders and new home sales for December will be released. Friday will bring the government's first look at fourth-quarter U.S. gross domestic product and the final January reading on consumer sentiment from Reuters and the University of Michigan.
But Wall Street is most likely to be preoccupied with earnings. Tuesday's agenda calls for quarterly results from Apple Inc (AAPL.O), DuPont (DD.N), Johnson & Johnson (JNJ.N), McDonald's Corp (MCD.N) and Yahoo! Inc (YHOO.O).
Boeing (BA.N), ConocoPhillips (COP.N) and United Technologies (UTX.N) are set to report results on Wednesday. Thursday's earnings line-up includes 3M Co (MMM.N), AT&T Inc (T.N) and Starbucks (SBUX.O). On Friday, Chevron Corp (CVX.N) and Procter & Gamble Co. (PG.N) will weigh in with results.
In terms of companies beating expectations, the fourth-quarter earnings season has not been as good as previous ones. Of the approximately 70 companies in the S&P 500 that have reported earnings so far, 60 percent have exceeded analysts' estimates, according to Thomson Reuters data.
In comparison, in the third quarter at this early point in the reporting cycle, 68 percent had beaten Wall Street's forecasts -- well below the 78 percent in that category in the second quarter, Thomson Reuters data showed.
In the earnings season so far, there have been some high-profile misses on both revenue and earnings.
General Electric Co's (GE.N) fourth-quarter revenue fell short of Wall Street's expectations, with Europe's weakening economy and weak appliance sales the main culprits.
On the other hand, banks' earnings have served as a positive catalyst for the stock market so far. The sector has been one of the market's leaders despite mixed earnings, a sign that investors' worst fears did not materialize.
(Reporting By Edward Krudy; Editing by Jan Paschal)
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To be clear I am not questioning Newt Gingrich and wife's Catholic life at this point. Life is a messy business and we are all sinners. Most of us fail to meet the mark and that is what Grace and the Church is for.
However I am not going where William A. Jacobson of the widely read Legal Insurrection blog is going. See Rick Santorum failed the debate character test
We can't wish this issue away and pretend it will not exist. It should alos be pointed out that Newt when he went for his effective Grand Slam last night in response did not defuse the issue. He basically said his wife was lying on the "open marriage" business. ( I mean what if a person thinks he is lying ? Does not make him a bad GOP person. ) .This is not going away. Further we cannot just ignore a ton of female voters in this race that might think WHOA what happened here. If you are a social conservative, like I am , then yes the baggage as to our potential standard banner counts.
As a Catholic ,I have lived through the Catholic abuse scandals. What the Catholic Church taught on marriage and related topics is as true today as it was 1900 years ago. However have no doubt that the weakness and mistakes of some in Church leadership are used to undermine that message. I get that everyday on issues from a to z. It does seem perhaps wise to consider how much of a liability that this might be
Now my personal opinion is I accept Newt's statements at face value. I understand how it is too fall and get back up. The problem is I am not sure I am in a position to tell others OH NO DON'T GO THERE. Even if I were it's not the reality we live in.
Mr Jacobson appears to have made a moral judgment on Rick Santorum's character at this point. That is fine. But the fact is people use all sorts of factors to make judgments. It's folly to ignore that . Also if Newt lied last night ( which I am not saying he did ) well is that fair game ? Already you can't escape it because Newt is putting people into positions of having to make judgments if he is telling the truth. That answer will differ to people no doubt. But a person's life goes into making that judgment.
Santorum is not failing any character test. He is telling the reality that we live in. That people are moral creatures and make moral judgments of acts and PERSONS everyday.
Source: http://opinionatedcatholic.blogspot.com/2012/01/rick-santorum-is-right-and-legal.html
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In his new book, Inside Apple, Fortune's Adam Lashinsky reveals a fact sure to shock anyone who views Apple as the quintessential Silicon Valley-culture company.
Apple employees have to pay for their own food.
What?!?!
At Google, Facebook, and other Valley icons, the free food and fun is legendary. What's going on at Apple? What OTHER things don't we know about the place? Well, for one thing, says Mr. Lashinsky, it's not much fun to work there, and you don't get paid all that much.
?
Produced by Robert Libetti & Daniel Goodman
Don't Miss:
Source: http://www.businessinsider.com/inside-a-2012-1
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Clusters of entangled qubits, shown in this artistic visualization, could allow remote quantum computing to be performed on a server while keeping the contents and results hidden from the remote server.
By Alan Boyle
If the future is heading toward "cloud computing," where most of your data lives on someone else's server, can you trust the cloud to keep a secret??Researchers say they've found a way to?guarantee that?your information will be?secure in the cloud, using quantum entanglement.
The technique is called blind quantum computing, and it adds one more piece to a puzzle that could eventually be assembled into an entirely?new infrastructure for data processing. Theoretically, quantum computers could outdo classical computers when it comes to making weather predictions, simulating biological processes, analyzing chemical reactions and, not incidentally, deciphering secret?codes. Data security could become an even bigger issue than it is today.
Whom do you trust?
Today, most of your computing power probably resides on the device you're using, whether it's a desktop or a smartphone. If you send secure data someplace else, those bits?are probably?encrypted using classical mathematical techniques. They're tough codes to break, but they're not unbreakable. In fact, computer scientists say quantum computers might be well-suited for?cracking today's classical codes.
At the same time, there's a trend toward developing devices that shift more of?the computing power onto big servers. You would still use your tablet or smartphone or netbook for input and output, but the information is stored and processed?as part of?a huge cloud of bits on the server. That's the idea behind the much-debated cloud computing approach.
How sure can you be that the folks who manage the cloud won't meddle with your data? And could a malicious cloud client meddle with the central server? Such questions are tricky now, and they could get trickier if quantum computing takes hold, according to an international?research team led by Stefanie Barz of the Vienna Center for Quantum Science and Technology at the University of Vienna and the Austria-based?Institute for Quantum Optics and Quantum Information.
In this week's issue of the journal Science, Barz and her colleagues note that quantum computers will be so complex that there may be only a few of them in operation at specialized facilities around the world.
"A key challenge in using such central quantum computers is enabling a quantum computation on a remote server while keeping the client's data hidden from the server," they write.
Demonstrating blind computing
The researchers?worked out a system to entangle photons of light that were generated by a nonlinear crystal, and then "process" those entangled?photons on an experimental?setup of beam splitters, filters?and couplers. The photons served as quantum bits, or qubits,?to be?manipulated?in?two types of?quantum calculations (Deutsch's algorithm and Grover's search).
In this scenario, the?person who provided the?qubits?knows their initial?entangled state, and?can thus?decipher the entangled outcome. But the company that does the data processing wouldn't know how the qubits were entangled ? and thus could not even try to?decode the?qubits without essentially destroying them. As far as it's concerned, all those qubits look like a totally random hodgepodge. What's more, the system has a built-in verification scheme.
"By inspecting the output, you can know if the company really has a quantum computer, without disclosing your algorithm, the input, or indeed the output," the University of Oxford's Vlatko Vedral said in a Science commentary on the research. "The computation is thus 'doubly' blind."
Barz and her colleagues say there are still some technical challenges to be overcome. for example, it's theoretically possible for some of the photons emitted while preparing the qubits to reveal information about the "blind" phase of the calculation. Also, it's important to have a high-fidelity, low-signal-loss system for processing the qubits ??whether they consist of photons with different polarizations, or electrons with different spins. But however the quantum computing puzzle is put together, the researchers say their?experiments will have contributed a key piece.
"Our demonstration is crucial for unconditionally secure quantum cloud computing," they say,?"and might become a key ingredient for real-life applications, especially when considering the challenges of making powerful quantum computers widely available."
More perspectives on the research:
More about?quantum computing:
Alan Boyle is msnbc.com's science editor. Connect with the Cosmic Log community by "liking" the log's Facebook page, following @b0yle on Twitter or adding Cosmic Log's Google+ page to your circle. You can also check out "The Case for Pluto," my book about the controversial dwarf planet and the search for other worlds.
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COLUMBIA, S.C. -- U.S. Supreme Court justice Antonin Scalia has a simple solution for people who don't like all the political advertisements unleashed by the court's decision two years ago that ended limits on corporate contributions in political campaigns ? change the channel or turn off the TV.
Scalia was asked about the decision during a presentation before the South Carolina Bar on Saturday, exactly two years after the court handed down the 5-4 decision in the case that led to the rise of Super PACs. They are outside groups affiliated with candidates that can take in unlimited contributions as long as they don't directly coordinate with the candidate.
"I don't care who is doing the speech ? the more the merrier," Scalia said. "People are not stupid. If they don't like it, they'll shut it off."
Scalia was joined on stage by Justice Stephen Breyer, who voted on the losing side in the decision which has become known as "Citizens United," for the group that successfully sued over federal campaign finance laws. Breyer didn't directly criticize the ruling, instead pointing out how it is critical in the American system that people respect the decisions the judiciary makes.
By nature, when a decision isn't unanimous, "somebody is making a mistake," Breyer said.
Breyer also briefly summarized both sides of the argument concentrating on his own.
"There are real problems when people want to spend lots of money on a candidate ... they'll drown out the people who don't have a lot of money," Breyer said.
Money flooding political races was a consequence predicted as soon as the decision was handed down in January 2010. And so far, it's true. Super PACs have raised more than $30 million just three races into the 2012 presidential race, according to the website opensecrets.org, run by The Center for Responsive Politics. TV advertising alone in South Carolina, which is voting Saturday, is estimated at $12 million, or nearly $27 per voter when calculated using the 2008 Republican primary turnout numbers.
Even U.S. Sen. Lindsey Graham poked jabs at the amazing amount of campaign ads on television as he introduced the justices.
"I miss seeing car ads," said Graham, R-S.C.
Scalia said the blame for this type of system shouldn't fall on the Supreme Court, which he said decides merely whether the system is legal under the U.S. Constitution. Instead, he said the ones who have to change things are the politicians who created the system and the voters who often reward the candidates who spend the most money.
"If the system seems crazy to you, don't blame it on the court," Scalia said, during a discussion in front of South Carolina lawyers that lasted for more than an hour.
Both justices refused to talk in detail about the health care legislation case the Supreme Court is scheduled to hear later this year.
Scalia spent more than 10 minutes lamenting the way confirmation hearings for new justices are now held in the U.S. Senate. He said lawmakers are now more concerned with making sure a prospective member of the court will interpret the Constitution they want, instead of the way the founding fathers wrote it.
"It's like conducting a mini constitutional convention every time you pick a justice," Scalia said.
Breyer said it's important for judges to take a flexible view of the Constitution. He said that, depending on a judge's interpretation, the clause allowing everyone equal rights under the law in the 14th Amendment meant making sure someone had the right to a lawyer, or the right to not be forced to give incriminating statements, or even the right to abortion or the right to choose to die when one wants.
"They look at those words and they say they apply to their cases too," Breyer said.
Related on HuffPost:
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This image courtesy of Mindy Tucker shows comedians Eliot, left, and Ilana Glazer as they pose for a photograph in New York. A video the siblings created about the things New Yorkers say has gone viral in the few days it's been posted, attracting lots of opinions of what New Yorkers do and don't say. (AP Photo/Mindy Tucker)
This image courtesy of Mindy Tucker shows comedians Eliot, left, and Ilana Glazer as they pose for a photograph in New York. A video the siblings created about the things New Yorkers say has gone viral in the few days it's been posted, attracting lots of opinions of what New Yorkers do and don't say. (AP Photo/Mindy Tucker)
NEW YORK (AP) ? Hip young New Yorkers hate waiting for the subway. They wouldn't be caught dead near tourist sites and couldn't care less if a celebrity walked by. They're snobby about what they read, even snobbier about what they eat, stick to their own borough, and call the most minuscule bedrooms "huge."
And there's something else: Some don't take kindly to being reduced to a cultural stereotype.
That's what Eliot and Ilana Glazer, brother-sister bloggers, comics and native New Yorkers, have discovered since their video, "Stuff New Yorkers Say" (no, the word isn't really "Stuff") has gone viral in the last couple days. Turns out, one of the things New Yorkers like to say is: "We don't say THAT!"
But there's been lots of positive feedback, too, and all the attention has stunned the Glazers, who posted the video on Wednesday night, hoping for some buzz but not expecting well over a million YouTube views (about 1.3 million as of late Friday).
"It's really bonkers," Eliot Glazer, 28, said in a telephone interview.
The video, inspired by a current Internet meme on what all sorts of groups of people say, is simple enough. In it, the Glazers and friends converse the way young New Yorkers would (or wouldn't, depending on whom you ask.) There are a few distinct themes.
Impatience: "Where is the train? Where is the TRAIN?" (There have been comments posted that while people in New York think this, they don't actually stand on the platform saying it.)
Exclusivity: "Nobody knows about this place."
Culinary exclusivity: "All I had today was a bagel." Or "Ah, Momofuku!" a reference to the group of restaurants headed by hip young chef David Chang.
Culinary snobbery: "Ah, Magnolia!" a reference to the cupcakes made famous by "Sex and the City" ? followed by a sour face, because the cupcakes aren't very hip.
Celebrity fatigue: "Sarah Jessica Parker! Oh, who cares."
Disdain for tourists: "Who goes to the Statue of Liberty?" ''Who goes to the Empire State Building?" ''Move! Move!" (walking down the street behind slowpokes.) "I hate tourists!"
That last theme, Glazer explains, is not to be taken literally. "New Yorkers are actually very kind to tourists," he says.
Another thing people are taking too literally, according to Glazer: The derisive comments about boroughs other than Manhattan, as in "I don't go to Queens," and "I don't do Brooklyn."
In fact, Glazer was born in Queens, grew up on Long Island, and now lives in Brooklyn, as does his sister ? a writer and comic whose Web series, "Broad City," is in development for the FX network.
Especially funny, Glazer says, is unwarranted speculation online that the Glazers aren't even from New York. But he says he doesn't read comments on YouTube: "It's just a pool of negativity."
"This is satire," he says. "We intended it to be a satire of what it means to be young and semi-spoiled in New York."
The video was shot and edited in about two weeks. "I was worried we were past the expiration date of the meme," Glazer says. He and his sister posted it to their Facebook accounts, and "within two hours it was insane ? the comments, the sharing," he says. "It was mind-blowing how quickly it took off."
What's clear from the video is that its creators love the city, despite its hardships.
Love-hate relationship with New York:
"I love it here.
"I hate it here.
"I love it here."
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